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Thursday, August 27, 2020

August 27, 2020
A health professional works at the Intensive Care Unit (ICU) ward where patients infected with the novel coronavirus are being treated. Credit: AFP

The Centers for Disease Control and Prevention quietly modified its coronavirus testing guidelines this week to exclude people who do not have symptoms of Covid-19 — even if they have been recently exposed to the virus.

Experts questioned the revision, pointing to the importance of identifying infections in the small window immediately before the onset of symptoms, when many individuals appear to be most contagious.

Models suggest that about half of transmission events can be traced back to individuals still in this pre-symptomatic stage, before they start to feel ill — if they ever feel sick at all.

“This is potentially dangerous,” said Dr Krutika Kuppalli, an infectious disease physician in Palo Alto, California. Restricting testing to only people with obvious symptoms of Covid-19 means “you’re not looking for a lot of people who are potential spreaders of disease,” she added. “I feel like this is going to make things worse.”
At a moment when experts have almost universally come forward to encourage more frequent and widespread testing, especially to reach vulnerable and marginalized sectors of the population, the CDC’s update appears counterintuitive and “very strange,” said Susan Butler-Wu, a clinical microbiologist at the Keck School of Medicine of the University of Southern California.

Just weeks ago, the National Institutes of Health announced the first round of grant recipients for its Rapid Acceleration of Diagnostics program, or RADx, to scale up coronavirus testing in the coming weeks and months. On the agency’s RADx website, officials underscore the importance of prioritizing tests that can “detect people who are asymptomatic.”

A more lax approach to testing, experts said, could delay crucial treatments, as well as obscure, or even hasten, the coronavirus’s spread in the community.

“I think it’s bizarre,” said Daniel Larremore, a mathematician and infectious diseases modeller at the University of Colorado Boulder. “Any move right now to reduce levels of testing by changing guidelines is a step in the wrong direction.”
Prior iterations of the CDC’s testing guidelines struck a markedly different tone, explicitly stating that “testing is recommended for all close contacts” of people infected with the coronavirus, regardless of symptoms. The agency also specifically emphasized “the potential for asymptomatic and pre-symptomatic transmission” as an important factor in the spread of the virus.

The newest version, which was posted on Monday, amended the agency’s guidance to say that people who have been in close contact with an infected individual — typically defined as being within 6 feet of a person with the coronavirus and for at least 15 minutes — “do not necessarily need a test” if they do not have symptoms. Exceptions, the agency noted, might be made for “vulnerable” individuals, or if health care providers or state or local public health officials recommend testing.

David Piegaro, who lives in Trenton, New Jersey, had sought out several tests for the coronavirus in recent months, after events like funerals and those that require travel because of his post in the National Guard.

He never experienced symptoms, and his tests have all been negative, bringing him peace of mind, especially because he lives with his parents and grandfather. “I viewed testing as a good thing to do,” he said. “Asymptomatic people could be spreading the virus, so widespread testing seems valuable.”

Tracking asymptomatic cases is also important from the perspective of the infected, Kuppalli said. Less than a year into this pandemic, experts still don’t know the full extent of the long-term consequences of contracting the coronavirus, even if the initial encounter seems benign.

The reasons behind the surprise shift in testing recommendations are unclear. In response to an inquiry from The New York Times, a representative for the CDC directed the questions to the US Department of Health and Human Services.

An HHS spokesperson said that asymptomatic testing could still be warranted “when directed by public health leaders or health care providers,” and noted that testing decisions should be “based on individual circumstances and the status of community spread.”

On Twitter, some people speculated that the Trump administration made the change to try to address continuing supply shortages, which have stymied testing efforts in many parts of the country, stretching turnaround times for results to weeks or more.

Many institutions and companies performing testing have prioritized people with symptoms in their lineup as a way to expedite the return of results for those most at risk for falling severely ill.

When asked about this, the HHS spokesperson said that the modification was not a response to sputtering supply chains. “Testing capacity has massively expanded, and we are not utilizing the full capacity that we have developed,” the spokesperson said. “We revised the guidance to reflect current evidence and the best public health interventions.”

Poorly timed testing, if conducted infrequently, could lead to false positives or false negatives, mistaking healthy people as infected or vice versa. That’s a potential risk if someone gets tested too soon after being exposed to the coronavirus, Butler-Wu pointed out.

Even so, anyone with a known exposure should quarantine and consider seeking a test, Kuppalli said, adding, “We still need to be careful.”

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